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This study addresses the use of Unani medicine and challenges toward this system in the contemporary world. The study is conducted in Tehsil Adenzai which is located in District Lower Dir Khyber Pakhtunkhwa Pakistan. The aim of conducting this study in the mentioned universe was that there are many Unani physicians in that area and they are practicing this system of medicine for many years. The study is qualitative in nature in which purposive sampling is used and face to face interview were conducted using interview guide. A total of 10 interviews were conducted based on saturation point. The finding reveals that Unani system of medicine is present in the area from many decades, they have unique form of diagnosing a disease and mostly uses herbal medicine to cure disease. Unfortunately, the Unani system of medicine faces problem in the contemporary world such there is no research and development in the field.